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KMID : 0620920110430010001
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Experimental & Molecular Medicine
2011 Volume.43 No. 1 p.1 ~ p.6
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Genetic controls of Th17 cell differentiation and plasticity
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Dong Chen
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Abstract
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CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2 cells, several novel effector T cell subsets have been recently identified, including Th17 cells. There has been rapid progress in characterizing the development and function of Th17 cells. Here I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases.
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KEYWORD
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CD4-positive T-lymphocytes, cell differentiation, cytokines, Th17 cells, transcription factors
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